(Streptokinase)
Indications and Usage
Acute Evolving Transmural Myocardial Infarction: Streptase® is indicated for use in the management of acute myocardial infarction (AMI) in adults, for the lysis of intracoronary thrombi, the improvement of ventricular function, and the reduction of mortality associated with AMI, when administered by either the intravenous or the intracoronary route, as well as for the reduction of infarct size and congestive heart failure associated with AMI when administered by the intravenous route.
Pulmonary Embolism: Streptase® is indicated for the lysis of objectively diagnosed (angiography or lung scan) pulmonary emboli, involving obstruction of blood flow to a lobe or multiple segments, with or without unstable hemodynamics.
Deep vein Thrombosis: Streptase® is indicated for the lysis of objectively diagnosed (preferably ascending venography), acute, extensive thrombi of the deep veins such as those involving the popliteal and more proximal vessels.
Arterial Thrombosis or Embolism: Streptase® is indicated for the lysis of acute arterial thrombi and emboli. Streptokinase is not indicated for arterial emboli originating from the left side of the heart due to the risk of new embolic phenomena such as cerebral embolism.
Occlusion of Arteriovenous Cannulae: Streptase® is indicated as an alternative to surgical revision for clearing totally or partially occluded arteriovenous cannulae when acceptable flow cannot be achieved.
Contraindications
Because thrombolytic therapy increase the risk of bleeding, Streptase® is contraindicated in the following situations:
Streptokinase should not be administered to patients having experienced severe allergic reaction to the product.
As with other fibrinolytics, use with caution in patients with conditions that increase the risk of hemorrhage, including use with antiplatelet agents, which may cause bleeding complications. Severe internal bleeding, allergic reactions, and rarely anaphylactoid reactions have been associated with Streptokinase therapy.
 Full prescribing information for Streptase®
|
